Dimethylglycine (DMG) is a popular substance in today's nutritional products. It will also be discussed as a corollary for vitamin B15, pangamic acid. DMG is an intermediary of cell metabolism, mainly from glycine and choline. As a precursor also to glycine, some of DMG's effects may be attributed to simple glycine, particularly in regard to its neuroinhibitory effect in problems such as epilepsy. DMG seems to be able to increase the immune antibody response and improve physical energy and has been used in the treatment of infections, immune suppression, fatigue, and poor endurance. Some people experience good results; others do not. More research is needed to properly understand dimethylglycine's role in clinical medicine.