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The Discovery that Changed the Direction of Heart Disease Research

© Interview With Dr. Daniel Steinberg
Interviewed By Richard A. Passwater Ph.D.


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1. Antioxidants in the prevention of human atherosclerosis.Steinberg, D. and Workshop ParticipantsCirculation 85:2338-2344 (1992)

2. Antiatherogenic effect of probucol unrelated to itshypocholesterolemic effect: Evidence that antioxidants invivo can selectively inhibit low density lipoproteindegradation in macrophage-rich fatty streaks slowing theprogression of atherosclerosis in the WHHL rabbit.Carew, T. E.; Schwenke, D. C. and Steinberg, D.Proc. Natl. Acad. Sci. 84:7725-9 (1987)

3. Probucol prevents the progression of atherosclerosis inWatanabe hyperlipidemic rabbit, an animal model for familialhypercholesterolemia.Kita, T.; Nagano, Y.; Yokode, M.; et al.Proc. Natl. Acad. Sci. 84:5928-31 (1987)

4. Probucol attenuates the development of aortic atherosclerosisin cholesterol-fed rabbits.Daugherty, A.; Zweifel, B. S. and Schonfeld, G.Br. J. Pharmacol. 98:612-8 (1989)

5. The antioxidant N,N'diphenyl-phenylenediamine preventsatherosclerosis in cholesterol-fed rabbits.Sparrow, C.; Doebber, T; Olszewski, J.; et al.Metabolism, p121 (abstract) (1992)

6. The antioxidant butylated hydroxytoluene protects againstatherosclerosis.Bjorkhem, I.; Henriksson-Freyschuss, A.; Breuer, O.; et al.Arterioscler. Thromb. 11:15-22 (1991)

7. Effects of d-alpha-tocopherol supplementation onexperimentally induced primate atherosclerosis.Verlangieri, Anthony J. and Bush, M. J.J. Amer. Coll. Nutr. 11:131-8 (1992)(Also see:Reversing atherosclerosis: An interview with Dr. AnthonyVerlangieri.Passwater, Richard A.Whole Foods p27-30 (August 1992)

8. A receptor-mediated pathway for cholesterol homeostasis.Brown, M. S. and Goldstein J. L.Science 232:34-47 (1986)

9. Binding site on macrophages that mediates uptake anddegradation of acetylated low-density lipoprotein, producingmassive cholesterol deposition.Goldstein, J. L.; Ho, Y. K.; Basu, S. K. and Brown, M. S.Proc. Natl. Acad. Sci. 76:333-7 (1979)

10. Enhanced macrophage degradation of low density lipoproteinpreviously incubated with cultured endothelial cells:Recognition by receptors for acetylated low densitylipoproteins.Henriksen, T.; Mahoney, E. M. and Steinberg, D.Proc. Natl. Acad. Sci. 78:6499-6503 (1981)

11. Modification of low density lipoprotein by endothelial cellsinvolves lipid peroxidation and degradation of low densitylipoprotein phospholipids.Steinbrecher, U. P.; Parthasarathy, S.; Leake, D. S.;Witztum, J. L. and Steinberg, D.Proc. Natl. Acad. Sci. 81:3883-7 (1984)

12. Endothelial cell-derived chemotactic activity for mouseperitoneal macrophages and the effects of modified forms oflow density lipoprotein.Quinn, M. T.; Parthasarathy, S. and Steinberg, D.Proc. Natl. Acad. Sci. 82:5949-5953 (1985)

13. Oxidatively modified low density lipoproteins: A potentialrole in recruitment and retention of monocyte/macrophagesduring atherogenesis.Quinn, M. T.; Parthasarathy, S.; Fong, L. G. andSteinberg, D.Proc. Natl. Acad. Sci. 84:2995-8 (1987)

14. Beyond cholesterol: Modifications of low density lipoproteinthat increase its atherogenicity.Steinberg, D.; Parthasarathy, S.; Carew, T. E.; Khoo, J. C.and Witztum, J. L.New Engl. J. Med. 320:915-24 (1989)

15. Enhanced macrophage uptake of low density lipoprotein afterself-aggregation.Khoo, J. C.; Miller, E.; McLoughlin, P. and Steinberg, D.Arteriosclerosis 8:348-58 (1988)



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     by Richard Passwater

Richard A. Passwater, Ph.D. has been a research biochemist since 1959. His first areas of research was in the development of pharmaceuticals and analytical chemistry. His laboratory research led to his discovery of ...more

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