Belladonna is unique, in that it suits headaches that are definitely relieved by sitting. Belladonna is one of a number of medicines that cover headaches made worse by climbing steps, but it alone fits those also aggravated by traveling down a slope or stairway. Afternoon is most characteristically the time of worst pain.

Bryonia is best used when the most prominent characteristic of the headache is aggravation with motion. Both Belladonna and Bryonia cover this marked sensitivity to motion, and many other remedies also fit headaches made worse by motion. For the Bryonia patient, however, this is the outstanding characteristic. Even slight motion of the head or eyes worsens the pain. The pain is made worse by slight touch but made better by firm pressure. It is generally worst in the morning, and though it may be felt immediately upon waking, it is just as likely to come on only after the person first moves in bed or after she gets out of bed. There is little throbbing with Bryonia headaches, unlike those of Belladonna, and the pain is described as a steady ache, sometimes with a sense of fullness or heaviness. As with Belladonna, the headache is likely to be located in the forehead, extending from there to the back of the head, but it is commonly centered over the left eye, a symptom not shared with Belladonna. Nausea, vomiting, and especially constipation may occur in connection with Bryonia headaches. The Bryonia patient is irritable and irascible and wants to be left alone.

Nux vomica is also a good medicine for irritable people with headaches. The apparent cause of the headache is most often the best indication for Nux, since this medicine frequently suits the symptoms of headaches brought on by overeating, the use of alcohol, coffee or other drugs, or staying up too late and missing sleep. The person with a typical morning hangover headache, who often has indulged in all of these pursuits, frequently is gratefully relieved with a dose or two of Nux. Such headaches are generally accompanied by an overall sick feeling and by digestive upsets. The sufferer may have a sour or bitter taste in the mouth in the morning, queasiness, nausea or vomiting (dry heaves and gas are especially typical Nux symptoms). The Nux headache may also be brought on by concentrated or prolonged mental work or by cold air or cold wind. In contrast to Bryonia headaches, those of Nux are worse in the morning, particularly upon first waking, and tend to get somewhat better after the person is up and about. As with most headaches, motion may aggravate the symptoms, but shaking the head is particularly painful (as in Belladonna). Lying on the painful side often makes the pain worse, and the sound of footsteps is particularly irritating to the Nux headache patient. Wrapping the head up or being in a warm room may relieve the pain.

Pulsatilla headaches have also been associated with digestive upsets. They often come on after meals and particularly after eating warm, rich, or fatty foods or after eating ice cream. Nausea and vomiting frequently accompany a Pulsatilla headache. Pulsatilla is also a good medicine for headaches that occur in connection with menstrual periods (before, during, or especially when the period ends) or those that result from a frightening experience. The pain is most often felt in the forehead or on one side of the head and may change location frequently (as it does with Sanguinaria). Throbbing accompanies the headache. Although walking briskly may make the pain worse, generally there is relief from gentle motion, especially walking about slowly in the open air. Pressure relieves the pain and blowing the nose aggravates it. The Pulsatilla individual is emotionally mild and sensitive and may weep from the pains. Though a little irritable, the person is likely to want company and consolation.