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N-Acetylcysteine (NAC): An Old Nutrient Attracts New Research


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61. N-acetylcysteine: Protective agent or promoter of gastricdamage?Lopez, R. A., et al,PSKBM 197:273-8 (1991)

62. N-acetylcysteine improves the survival rate of paraquatpoisoned rats: Elucidation of its mode of action.Hoffer, E., et al,Rev. Respir. Dis. 143(4 part 2) A731 (1991)

63. Allopurinol/N-acetylcysteine for carbon monoxide poisoning.Howard, R. J. M. W., et al,Lancet II 628-9 (1987)

64. Acute carbon tetrachloride poisoning in 19 patients:Implications for diagnosis and treatment.Ruprah, M., Mant, T. G. and Flanagan, R. J.Lancet I 1027-9 (1985)

65. Survival after iassive ingestion of carbon tetrachloridetreated by intravenous infusion of acetylcysteine.Mathieson, P. W., Williams, G. and MacSweeney, J. E.Hum. Toxicol. 4(6):627-31 (1985)

66. Inhibition of urethane-induced lung tumors in mice bydietary N-acetylcysteine.De Flora, Silvio, et al,Cancer Lett. 32(3):235-41 (1986)

67. Identification of N-acetyl-S-(N-methylcarbamoyl)cysteine:A human metabolite of N,N-dimethylformamide andN-methylformamide.Mraz, J. and Turecek, F.J. Chromatogr. 414(2)399-404 (1987)

68. N-acetylcysteine prevents diaphragmatic contractilealterations induced by Escherichia-coli endotoxemiain rats.Du, Y., Boczkowski, J. and Aubier, M.Rev. Respir. Dis. 143 (4 part 2) A560 (1991)

69. Urinary excretion of thiol conjugates of aflatoxin B1 inrats and hamsters.Raj, H. G. and Lotlikar, P. D.Cancer Lett. 22(2):125-33 (1984)

70. Modifying role of dietary factors on the mutagenicity ofaflatoxin B1: In vitro effect of sulfur-containing aminoacids.Shetty, T. K., Francis, A. R. and Bhattacharya, R. K.Mutat. Res. 222(4):403-7 (1989)

71. Metabolic, desmutagenic and anticarcinogenic effects ofN-acetylcysteine.De Flora, Silvio, Rossi, G. A. and De Flora, A.Respiration 30(suppl. 1):43-9 (1986)

72. In vitro effects of N-acetylcysteine on the mutagenicity ofdirect-acting compounds and procarcinogens.De Flora, Silvio, et al,Carcinogenesis 5(4):505-10 (1984)

73. In vivo effects of N-acetylcysteine on glutathionemetabolism and on the biotransformation of carcinogenicand/or mutagenic compounds.De Flora, Silvio, et alCarcinogenesis 6(12):1735-45 (1985)

74. Detoxification of genotoxic compounds as a thresholdmechanism limiting their carcinogenicity.De Flora, S.Toxicol. Pathol. 12(4):337-43 (1984)

75. Effects of N-acetyl-L-cysteine and ascorbic acid onmutagen-induced chromosomal sensitivity in patients withhead and neck cancers.Trazana, Zoltan, et al,Amer. J. Surg. 162:294-8 (1991)

76. Effect of exogenous glutathione on tumor progression in themurine skin multistage carcinogenesis model.Rotstein, J. B. and Slaga, T. J.

77. Second-line chemotherapy in small-cell lung cancer.Andersen, M., Kristjansen, P. E. G. and Hansen, H. H.Cancer Treat. Rev. 17(4):427-36 (1990)

78. N-acetylcysteine as chemoprotectant in cancer chemotherapy.Martinez, Esteban and Domingo, PereLancet 338:249 (July 27, 1991)

79. Long-term oral acetylcysteine in chronic bronchitis: Adouble-blind controlled study.Multicenter Study GroupEur. J. Respir. Dis. 61(Sup.):93 (1980)

80. The reduction in vitro in viscosity of mucoproteinsolutions by a new mucolytic agent, N-acetylcysteine.Sheffner, A. L.Ann. NY Acad. Sci. 106:288 (1963)



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     by Richard Passwater

Richard A. Passwater, Ph.D. has been a research biochemist since 1959. His first areas of research was in the development of pharmaceuticals and analytical chemistry. His laboratory research led to his discovery of ...more

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