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N-Acetylcysteine (NAC): An Old Nutrient Attracts New Research


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42. AIDS - Drug therapy; Acetylcysteine research.Cooper, MikeCDC AIDS Weekly p4 (Oct. 2, 1989)

43. Glutathione deficiency and radiosensitivity in AIDSpatients.Vallis, K. A.The Lancet 337:918-9 (April 13, 1991)

44. Comparative study of the anti-HIV activities of ascorbateand thiol-containing reducing agents in chronicallyHIV-infected cells.Harakeh, Steve and Jariwalla, Raxit J.Amer. J. Clin. Nutr. 54:1231S-5S (1991)

45. Inhibition of HIV-1 replication and NF-kappa B activity bycysteine and cysteine derivatives.Mihm, S., et al,AIDS 5(5):497-503 (May 1991)

46. Intracellular glutathione level controls DNA-bindingactivity of NF kappa B-like proteins. Mihm, S. and Droge, W.Int. Conf. AIDS 6(3):159 (abst. # SA311) (June 20-3, 1990)

47. Coenzyme Q10 increases T4/T8 ratios of lymphocytes inordinary subjects and relevance to patients having the AIDSrelated complex. Folkers, Karl, et al,Biochem. Biophys. Res. Commun. 176(2):786-91 (April 30, 1991)

48. Clinical application for heavy metal-complexing potential ofN-acetylcysteine.Lorber, A., et al,J. Clin. Pharmacol. 13:332-6 (1973)

49. N-acetylcysteine therapy of acute heavy metal poisoning inmice.Henderson, P., et al,Vet. Hum. Toxicol. 27:522-5 (1985)

50. Treatment of acute methylmercury ingestion byhemodialysis with N-acetylcysteine.Lund, M. E., Clarkson, T. W. and Berlin, M.J. Toxicol. Clin. Toxicol. 22:31-49 (1984)

51. Lung and blood superoxide dismutase activity in mercuryvapor exposed rats.Livardjani, F. et al,Toxicol. 66(3):289-95 (1991)

52. Effectiveness of N-acetylcysteine in protecting againstmercuric chloride-induced nephrotoxicity.Girardi, G. and Elias M. M.Toxicol. 67(2):155-64 (1991)

53. Experimental chelation therapy in chromium, lead and boronintoxification with N-acetylcysteine.Tong, T. G.Toxicol. Appl. Pharmacol. 83:142-7 (1986)

54. The role of glutathione in detoxification.Ketterer, B., Coles, B. and Meyer, D. JEnvir. Health Perspec. 49:59-69 (1983)

55. Mechanism of action of N-acetylcysteine in the protectionagainst hepatotoxicity of acetaminophen in rats in vivo.Lauterburg, B. H., Corcoran, G. B. and Mitchell, J. R.J. Clin. Invest. 71:980-991 (1983)

56. Role of glutathione in prevention of acetaminophen-inducedhepatotoxicity by N-acetyl-L-cysteine in vivo.Corcoran, G. B. and Wong, B. K.J. Pharmacol. Exp. Ther. 238:54-61 (1986)

57. Effect of N-acetylcysteine on plasma cysteine andglutathione following paracetamol administration.Burgunder, J. M., Varriale, A. and Lauterberg, B. H.Eur. J. Clin. Pharmacol. 36:127-31 (1989)

58. The disposition and kinetics of intravenousN-acetylcysteine in patients with paracetamol overdosage.Prescott, L. F., et al,Eur. J. Clin. Pharmacol. 37:501-6 (1989)

59. Improvement by acetylcysteine of hemodynamics and oxygentransport in fulminant hepatic failure.Harrison, Phillip M., et al,N. Engl. J. Med. 324(26):1852-7 (June 27, 1991)

60. Identification and characterization of the glutathione andN-acetylcysteine conjugates of E-2, Propyl-2,4-pentadienoicacid (a toxic metabolite of valproic acid in rats andhumans.Kassahun, K. Farrell, K. and Abbott, F.Drug Metab. Dispos. 19(2):525-35 (1991)



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     by Richard Passwater

Richard A. Passwater, Ph.D. has been a research biochemist since 1959. His first areas of research was in the development of pharmaceuticals and analytical chemistry. His laboratory research led to his discovery of ...more

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