In Europe vitamin B15 has been used to treat premature aging, because of both its circulatory stimulus and its antioxidant effect. It is felt to be a helpful protectant from pollutants, especially carbon monoxide. Pangamic acid (and possibly DMG) support for anyone living in a large polluted city or with a high-stress lifestyle could be a wave of the future.

In Russia, a big use of pangamic acid has been for treating those with alcohol problems, possibly reducing the craving. It has been reported to diminish hangover symptoms when alcohol has been abused. B15 has also been used to treat fatigue, as well as asthma and rheumatism, and it may even have some antiallergic properties. Some child psychiatrists have reported good results using pangamic acid in disturbed children; it may help by stimulating speaking ability and other mental functions. B15 may also be useful in problems of autism.

More studies regarding all claims of the benefits of pangamic acid must be done, of course, to see which ones may be valid. But as of now, it certainly is a "vitamin" or supplemental nutrient with potential health benefits and research interest.

Deficiency and toxicity: There are no known toxic effects from even high amounts of pangamic acid; 50–100 mg. (and even more) taken three times daily have revealed no side effects. There are reports of initial mild nausea with use of pangamates at high levels, but this only lasts a few days.

There is limited information about deficiencies of pangamic acid. There are no clear problems when it is absent in the diet, though some diminished circulatory and oxygenation functions are possible. Decreased cell respiration—that is, decreased oxygen use by cells—may influence many other cellular functions which may lead to effects on the heart.

Requirements: There is no RDA for pangamic acid. At the time of this writing, it is not legal to distribute B15 in the United States, though it was used as a supplement for some time in the 1970s. The most common form of pangamic acid was calcium pangamate, but currently it is dimethyl glycine (DMG), which may even be the active component that has been hailed in the Soviet Union. Pangamic acid or DMG, when used, is often taken with vitamin E and vitamin A. A common amount of DMG is 50–100 mg. taken twice daily, usually with breakfast and dinner. This level of intake may improve general energy levels, support the immune system, and is also thought to reduce cravings for alcohol and thus may be very helpful in moderating chronic alcohol problems.