Citations from the Medline database for Allium sativum

Aboul-Enein AM: Inhibition of tumor growth with possible immunity by Egyptian garlic extracts.

NAHRUNG 1986; 30(2):161-9

Garlic bulbs (Allium sativum) were extracted with distilled water or ethanol. The extracts were then incubated with Ehrlich ascites carcinoma cells at 37 degrees C for 1 h. These pretreated cells were injected into swiss albino mice which survived over 12 weeks. To the contrary, tumor cells which were pretreated with garlic extracts, produced ascites tumor in all mice that died 2 or 4 weeks after intraperitoneal injection. When mice were treated twice at intervals of 7 days with freshly prepared tumor cells exposed to watery or ethanolic extracts of fresh garlic, they acquired resistance against a challenge with Ehrlich ascites tumor cells. Administration of garlic extracts to mice for at least 2 weeks before tumor transplantation, caused a slight delay of 10-20 days in tumor growth and animal death. Generally, the ethanolic extract of garlic gave more pronounced effect as tumor inhibitor as well as immunityinduction than watery extract. No change in serum electrophoreticpattern was detected in mice, whether the tumor cells injected wereincubated or not with garlic extract. In animals treated withunincubated tumor cells, albumin and globulin percentages as well as albumin: globulin ratios (A/G) were decreased as compared to normalmice. A/G ratio was also decreased in immunized mice, pretreated with garlic extract, due to the increase of gamma globulin and unchanging of albumin.

Adoga GI: Effect of garlic oil extract on glutathione reductase levels in rats fed on high sucrose and alcohol diets: a possible mechanism of the activity of the oil.

BIOSCI REP 1986 Oct; 6(10):909-12

The effect on glutathione reductase activities of feeding garlic oil to white albino rats maintained on high sucrose and alcohol diets was studied. Whereas high sucrose and alcohol diets resulted in significant increases in the activity of glutathione reductase in liver, kidneys and serum, the presence of garlic oil restored the levels to near normal. It is proposed that the mechanism of this action of garlic oil involves the active principle, diallyl disulphide, which interacts in an exchange reaction with enzymes and substrates such as glutathione reductase and glutathione which contain thiol groups.

Adoga GI Osuji J: Effect of garlic oil extract on serum, liver and kidney enzymes of rats fed on high sucrose & alcohol diets.

BIOCHEM INT 1986 Oct; 13(4):615-24

High levels of alkaline phosphatase and alcohol dehydrogenase were observed in the serum, liver and kidneys of rats fed on high sucrose and high alcohol diets over a period of 75 days. Garlic oil extract fed with any of the diets, significantly lowered the high levels of the two enzymes in the serum, liver and kidneys. This effect may be due to reduced biosynthesis of fatty acids as NADPH, required for the process, is utilised for the metabolism of the oil.

Ahn-B-W; Lee-D-H; Yeo-S-G; Kang-J-H; Do-J-R; Kim-Y-H; Park-Y-H

Inhibitory action of natural food components on the formation of carcinogenic nitrosamine.

Bulletin of the Korean Fisheries Society (1993) 26(4): 289-295