| Hydrastis canadensis
Ranunculaceae
Names: Orange Root, Yellow Root.
Habitat: Native to North America, it was used extensively by Native Americans as an herbal medication and clothing dye. Its medicinal use centered around its ability to soothe the mucous membranes of the respiratory, digestive, and genitourinary tracts in inflammatory conditions induced by allergy or infection. It is mostly cultivated.
Collection: Unearth root and rhizome from three-year-old plants in the autumn, after the ripening of the seeds. Clean carefully and dry slowly in theair.
Part Used: Root and rhizome.
Constituents: - Isoquinoline alkaloids, mainly hydrastine, berberine, berberastine, canadine, candaline, and hydrastinine.
- Miscellaneous; fatty acids, resin, polyphenolic acids, meconin, chlorogenic acid, phytosterins and a small amount of volatile oil.
Actions: Bitter, hepatic, alterative, anti-catarrhal, anti-microbial, anti-inflammatory, astringent, laxative, expectorant, emmenagogue, oxytocic.
Indications: One of our most useful remedies owing much of its value to the tonic effects it has on the mucous membranes of the body. This is why itis of such help in all digestive problems, from peptic ulcers to colitis. Its bitter stimulation helps in loss of appetite, and the alkaloids it contains stimulate bile production and secretion. All catarrhal conditions improve with Golden Seal, especially sinus ones. The anti-microbial properties appear to due to alkaloids present. As an example of research that has been done on plant constituents we shall consider berberine. Berberine, found in a number of other herbs as well, has antibiotic, immuno-stimulatory, antispasmodic, sedative, hypotensive, uterotonic, cholerectic, & carminative activity. Its demonstrable pharmacological activities strongly contribute to the therapeutic use of Hydrastis. Berberine has marked antimicrobial activity, and whilst not in the same league as antibiotics, ithas a broad spectrum of antimicrobial activity. In vitro antimicrobial effects have been demonstrated against bacteria, protozoa, and fungi, including:
Staphyloccus spp.
Streptoccus spp.
Chlamydia spp.
Corynebacterium diphtheria
Escherichia coli
Salmonella typhi
Vibrio cholerae
Diplococcus pneumonia
Pseudomonas spp.
Shigella dysenteriae
Entamoeba histolytica
Trichomonas vaginalis
Neisseria gonorrhoeae
Neisseria meningitidis
Treponema pallidum
Giardia lamblia
Leishmania donovani
Candida albicans.
Berberine's action against some of these pathogens is actually stronger than that of antibiotics commonly used, however, please remember that we are dealing with whole plants and not extracted constituents. Berberine'saction in inhibiting Candida, as well as other pathogenic bacteria, prevents the overgrowth of yeast that is a common side effect of antibiotic use. This fascinating alkaloid increases blood supply to the spleen. This improved blood supply may promote optimal activity of the spleen by increasing the release of compounds that potentiate immune response. It has also been shown to activate macrophages in a number of ways. Coupled with its ability to inhibit tumor formation in the laboratory, suggests that berberine possesses some antineoplastic activity.
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Whilst working in conservation and lecturing in ecology and the eco-crisis for the University of Wales, David Hoffman became convinced that to heal the world, to embrace planetary wholeness and responsibility for it 
