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Which of the following is an antioxidant?
Vitamin E
Vitamin B


 Interviews with Nutritional Experts: The Discovery that Changed the Direction of Heart Disease Research  
Interview with Dr. Daniel Steinberg
   as interviewed by Richard A. Passwater PhD

1. Antioxidants in the prevention of human atherosclerosis.Steinberg, D. and Workshop ParticipantsCirculation 85:2338-2344 (1992)

2. Antiatherogenic effect of probucol unrelated to itshypocholesterolemic effect: Evidence that antioxidants invivo can selectively inhibit low density lipoproteindegradation in macrophage-rich fatty streaks slowing theprogression of atherosclerosis in the WHHL rabbit.Carew, T. E.; Schwenke, D. C. and Steinberg, D.Proc. Natl. Acad. Sci. 84:7725-9 (1987)

3. Probucol prevents the progression of atherosclerosis inWatanabe hyperlipidemic rabbit, an animal model for familialhypercholesterolemia.Kita, T.; Nagano, Y.; Yokode, M.; et al.Proc. Natl. Acad. Sci. 84:5928-31 (1987)

4. Probucol attenuates the development of aortic atherosclerosisin cholesterol-fed rabbits.Daugherty, A.; Zweifel, B. S. and Schonfeld, G.Br. J. Pharmacol. 98:612-8 (1989)

5. The antioxidant N,N'diphenyl-phenylenediamine preventsatherosclerosis in cholesterol-fed rabbits.Sparrow, C.; Doebber, T; Olszewski, J.; et al.Metabolism, p121 (abstract) (1992)

6. The antioxidant butylated hydroxytoluene protects againstatherosclerosis.Bjorkhem, I.; Henriksson-Freyschuss, A.; Breuer, O.; et al.Arterioscler. Thromb. 11:15-22 (1991)

7. Effects of d-alpha-tocopherol supplementation onexperimentally induced primate atherosclerosis.Verlangieri, Anthony J. and Bush, M. J.J. Amer. Coll. Nutr. 11:131-8 (1992)(Also see:Reversing atherosclerosis: An interview with Dr. AnthonyVerlangieri.Passwater, Richard A.Whole Foods p27-30 (August 1992)

8. A receptor-mediated pathway for cholesterol homeostasis.Brown, M. S. and Goldstein J. L.Science 232:34-47 (1986)

9. Binding site on macrophages that mediates uptake anddegradation of acetylated low-density lipoprotein, producingmassive cholesterol deposition.Goldstein, J. L.; Ho, Y. K.; Basu, S. K. and Brown, M. S.Proc. Natl. Acad. Sci. 76:333-7 (1979)

10. Enhanced macrophage degradation of low density lipoproteinpreviously incubated with cultured endothelial cells:Recognition by receptors for acetylated low densitylipoproteins.Henriksen, T.; Mahoney, E. M. and Steinberg, D.Proc. Natl. Acad. Sci. 78:6499-6503 (1981)

11. Modification of low density lipoprotein by endothelial cellsinvolves lipid peroxidation and degradation of low densitylipoprotein phospholipids.Steinbrecher, U. P.; Parthasarathy, S.; Leake, D. S.;Witztum, J. L. and Steinberg, D.Proc. Natl. Acad. Sci. 81:3883-7 (1984)

12. Endothelial cell-derived chemotactic activity for mouseperitoneal macrophages and the effects of modified forms oflow density lipoprotein.Quinn, M. T.; Parthasarathy, S. and Steinberg, D.Proc. Natl. Acad. Sci. 82:5949-5953 (1985)

13. Oxidatively modified low density lipoproteins: A potentialrole in recruitment and retention of monocyte/macrophagesduring atherogenesis.Quinn, M. T.; Parthasarathy, S.; Fong, L. G. andSteinberg, D.Proc. Natl. Acad. Sci. 84:2995-8 (1987)

14. Beyond cholesterol: Modifications of low density lipoproteinthat increase its atherogenicity.Steinberg, D.; Parthasarathy, S.; Carew, T. E.; Khoo, J. C.and Witztum, J. L.New Engl. J. Med. 320:915-24 (1989)

15. Enhanced macrophage uptake of low density lipoprotein afterself-aggregation.Khoo, J. C.; Miller, E.; McLoughlin, P. and Steinberg, D.Arteriosclerosis 8:348-58 (1988)

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 About The Author
Richard A. Passwater, Ph.D. has been a research biochemist since 1959. His first areas of research was in the development of pharmaceuticals and analytical chemistry. His laboratory research led to his discovery of......moreRichard Passwater PhD
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