Skip Navigation Links



    Learn More     Subscribe    
Join Now!      Login
Breathing Quiz
Which of the following health conditions is not directly benefited by breathing exercises?
atural Medicine Research

Pregnenolone and memory

© Ray Sahelian MD

The following is one in an ongoing series of columns entitled Natural Medicine Research by Ray Sahelian MD. View all columns in series
Ray Sahelian Pregnenolone is a hormone made by the adrenal glands, brian, and other organs. It is made from cholesterol and then used by the body to convert into DHEA, progesterone, testosterone, estrogen, and other hormones. Supplements of pregnenolone became available over the counter in 1995. Many laboratory studies performed on rodents have shown this hormone to be an extremely powerful memory enhancer. The mechanism for this action is not fully known but probably involves a number of mechanisms. One possibility is the effect of Preg on the brain chemical acetylcholine, which is known to be involved with memory.

In this study, pregnenolone was given to rats directly in the fluid bathing the brain. Following Preg administration, there was an increase in acetylcholine levels in the cerebrum. The increase in cortical acetylcholine reached a maximum thirty minutes after administration. This result suggest that Preg interacts with the cortical cholinergic system, which may account, at least in part, for the memory-improving properties of this hormone.

Comments: The crucial role that hormones play in the brain is gradually being discovered. Unfortunately there has been very little thus far on the role of pregnenolone in human cognition. Thus, safe and effective dosages have not yet been established. You will often find Preg sold in dosages of 5, 10, 25, 30, 50, and even 100 mg. Although the high dosages may be useful in certain conditions when used temporarily under medical supervision, I urge both consumers and health care practitioners to limit their dosages when taking Preg for the long term. The appropriate dosages for long term use may be as low as 1 to 3 mg. Preg is a powerful hormone and needs to be treated cautiously.

Darnaudery M. The neurosteroid pregnenolone sulfate increases cortical acetylcholine release: a microdialysis study in freely moving rats. J Neurochem 1998 Nov;71(5):2018-22

Add your comment      
About The Author
Ray Sahelian, M.D., is a popular and respected physician who has been seen on numerous television programs including NBC Today, Dateline NBC, and CNN, and quoted by countless major magazines such as Newsweek He is the bestselling author of Mind Boosters, Natural Sex Boosters, and ...more
Share   Facebook   Buzz   Delicious   Digg   Twitter  
From Our Sponsor
Featured Events
Wellness Inventory Certification Training
     September 16-December 16, 2014
     Teleclass, CA USA
Additional Calendar Links
Wellness, Intimacy, dimension!

Home       Wellness       Health A-Z       Alternative Therapies       Find a Practitioner       Healthy Products       Bookstore       Wellness Inventory
Healthy Kitchen       Healthy Woman       Healthy Man       Healthy Child       Healthy Aging       Wellness Center       Nutrition Center       Fitness Center
Free Newsletter      What Doctor's Don't Tell You      Discount Lab Tests      First Aid      Global Health Calendar      Privacy Policy     Contact Us

Disclaimer: The information provided on HealthWorld Online is for educational purposes only and IS NOT intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek professional medical advice from your physician or other qualified healthcare provider with any questions you may have regarding a medical condition.