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 New Canadian study: Glucosamine hydrochloride shows potential positive benefits  
The following is one in an ongoing series of columns entitled Natural Medicine Research by . View all columns in series
Ray Sahelian The results of the first North American study with glucosamine hydrochloride were presented at the July 1998 meeting of the 12th Panamerican Congress of Rheumatology in Montreal, Canada. Dr. Joseph Houpt, from Mount Sinai Hospital, University of Toronto, Canada, in cooperation with Dr. Allan Russell, from Brampton Pain Clinic in Brampton, Ontario, Canada, gave 47 individuals with osteoarthritis glucosamine hydrochloride 500 mg three times a day for 8 weeks. They compared the results to a placebo group of 47 individuals. At the conclusion of the study, 49 percent of those receiving glucosamine noted benefits. However, it appears that there is a high placebo effect in osteoarthritis since 45 percent of those on placebo also reported feeling better. Part of the reason of the high response from the placebo group may be due to pre-study media hype. Patient expectations may have had a significant effect on the clinical responses.

The researchers noted an improvement in the knee examination of patients in the glucosamine group from the 4th to the 8th week. Dr. Russell adds, "The most impressive finding was the significant decrease in pain which started at the 4th week and accelerated with time." Mild gastrointestinal side effects were seen in 12 percent in both groups.

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 About The Author
Ray Sahelian, M.D., is a popular and respected physician who has been seen on numerous television programs including NBC Today, Dateline NBC, and CNN, and quoted by countless major magazines such as Newsweek He......moreRay Sahelian MD
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