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 Urinary Tract Infections: Urinary Tract Conditions: Examining the Evidence on Cranberry and Saw Palmetto 
 
National Institutes of Health National Center for Complementary and Alternative Medicine ©

Given the mixed research results, the high level of consumer interest in phytotherapeutic agents for BPH, and the remaining scientific questions, results are anticipated from a large RCT now under way—Complementary and Alternative Medicine for Urological Symptoms, or CAMUS. This trial is studying saw palmetto, compared with placebo, for preventing clinical progression of BPH over a longer term (18 months) than in earlier RCTs. CAMUS is taking place at 10 clinical centers, led by the University of Alabama at Birmingham. The National Institute of Diabetes and Digestive and Kidney Diseases, NCCAM, and the NIH Office of Dietary Supplements are the cosponsors.

For More Information

Sources

Sources consist of Federal publications, recent systematic reviews and meta-analyses in PubMed, the National Guideline Clearinghouse, and a selection of evidence-based databases.

  • Abrams P, Chapple C, Khoury S, et al. Evaluation and treatment of lower urinary tract symptoms in older men. Journal of Urology. 2009;181(4):1779–1787.
  • American College of Obstetricians and Gynecologists. Treatment of Urinary Tract Infections in Nonpregnant Women. Washington, DC: American College of Obstetricians and Gynecologists; 2008. ACOG practice bulletin no. 91.
  • American Urological Association. Guideline on the Management of Benign Prostatic Hyperplasia. 2003 (revised 2006). AUA Web site. Accessed on September 15, 2009.
  • Barnes PM, Bloom B, Nahin R. Complementary and alternative medicine use among adults and children: United States, 2007. CDC National Health Statistics Report #12. 2008.
  • Bent S, Kane C, Shinohara K, et al. Saw palmetto for benign prostatic hyperplasia. New England Journal of Medicine. 2006;354(6):557–566.
  • Boyle P, Robertson C, Lowe F, et al. Updated meta-analysis of clinical trials of Serenoa repens extract in the treatment of symptomatic benign prostatic hyperplasia. BJU International. 2004;93(6):751–756.
  • Cranberry. Natural Medicines Comprehensive Database Web site. Accessed on June 29, 2009.
  • Dedhia RC, McVary KT. Phytotherapy for lower urinary tract symptoms secondary to benign prostatic hyperplasia. Journal of Urology. 2008;179(6):2119–2125.
  • Guay DR. Cranberry and urinary tract infections. Drugs. 2009;69(7):775–807.
  • Head KA. Natural approaches to prevention and treatment of infections of the lower urinary tract. Alternative Medicine Review. 2008;13(3):227–244.
  • Jepson RG, Craig JC. Cranberries for preventing urinary tract infections. Cochrane Database of Systematic Reviews. 2008;23(1):CD001321.
  • Jepson RG, Mihaljevic L, Craig JC. Cranberries for preventing urinary tract infections. Cochrane Database of Systematic Reviews. 2004;(2):CD001321.
  • Jepson RG, Mihaljevic L, Craig JC. Cranberries for treating urinary tract infections. Cochrane Database of Systematic Reviews. 1998 (updated 2009);(4):CD001322.
  • Litwin MS, Saigal CS, eds. Urologic Diseases in America. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases. Washington, DC: U.S. Government Printing Office, 2007; NIH publication no. 07–5512.
  • Lynch DM. Cranberry for prevention of urinary tract infections. American Family Physician. 2004;70(11):2175–2177.
  • National Institute of Diabetes and Digestive and Kidney Diseases. Prostate Enlargement: Benign Prostatic Hyperplasia. NIDDK Web site. Accessed on September 15, 2009.
  • National Institute of Diabetes and Digestive and Kidney Diseases. Urinary Tract Infections in Adults. NIDDK Web site. Accessed on September 15, 2009.
  • Natural medicines in the clinical management of benign prostatic hyperplasia. Natural Medicines Comprehensive Database Web site. Accessed at on June 29, 2009.
  • Tacklind J, MacDonald R, Rutks I, et al. Serenoa repens for benign prostatic hyperplasia. Cochrane Database of Systematic Reviews. 2009;(2):CD001423.
  • Ulbricht C, Basch E, Bent S, et al. Evidence-based systematic review of saw palmetto by the Natural Standard Research Collaboration. Journal of the Society for Integrative Oncology. 2006;4(4):170–186.
  • Wilt T, Ishani A, MacDonald R. Serenoa repens for benign prostatic hyperplasia. Cochrane Database of Systematic Reviews. 2002;(3):CD001423.
  • Wilt T, Ishani A, Stark G, et al. Serenoa repens for benign prostatic hyperplasia. Cochrane Database of Systematic Reviews. 2000;(2):CD001423.

Acknowledgments

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