Skip Navigation Links



    Learn More     Subscribe    
Join Now!      Login
Medicial Mistakes Quiz
How many people each year suffer some type of preventable harm that contributes to their death after a hospital visit?
ntegrative Medicine
Prozac and Beyond-The Synthetic Antidepressants

© Hyla Cass MD

Desyrel (trazodone hydrochloride) works on the serotonin system. Rather than being used for its antidepressant effects, it is most often prescribed along with Prozac because the drowsiness Desyrel induces counteracts Prozac's tendency to produce insomnia. Desyrel's other side effects include headache, upset stomach, low blood pressure, dizziness, and dry mouth. In men, it can also cause a dangerous condition called priapism-painful, drug-induced erections that may not end upon discontinuing the drug. These side effects explain why Desyrel is seldom prescribed as an antidepressant.

Effexor (venlafaxine hydrochloride) is chemically similar to an antidepressant compound in chocolate known as phenylethylamine (PEA), sometimes associated with the "love effect." It is likely that PEA raises the level of endorphins in the brain, which creates a sense of well-being. The tradition of giving chocolates on Valentine's Day reflects our intuitive knowledge of this effect.

Effexor is able to inhibit serotonin re-uptake as effectively as Prozac, yet it also boosts norepinephrine levels much as the tricyclic drugs do. That means it provides the benefits of the tricyclic medications without producing many of their side effects. Effexor also provides benefits for nearly half of the patients who do not respond to other antidepressant drugs, a far higher response rate than for other medications.

However, some 37 percent of the patients who try Effexor report problems with nausea, and one in every five persons experience dizziness, drowsiness, or dry mouth. Sleep disturbances can occur, as well. It can also increase blood pressure, so persons with high blood pressure should avoid the drug. On the good side, it does not seem to intensify the effects of tranquilizers or alcohol. It must be taken two or three times per day due to its short half-life, and dosages should be tapered off over two weeks to avoid withdrawal symptoms of severe rebound anxiety and depression. This can be extremely disabling, and sometimes even dangerous. I have seen suicidal depression result from sudden Effexor withdrawal.

The Problem of Side Effects
Scientific studies and the personal experiences of millions of patients have given us new insight into the frequent side effects produced by synthetic antidepressants. We now know that some of these medications can cause problems in up to a third of all users, forcing some to stop treatment altogether. We have also learned that particular classes of drugs are better tolerated than others. The MAOIs, for example, have fewer side effects than the tricyclics, but still produce multiple actions within the body that are unrelated to depression. These drugs can be particularly troublesome, even life-threatening, when taken in combination with certain foods or chemicals.

The reason for these side effects is related to the nature of synthetic drugs. When we affect one system in the body, we often affect others in both a positive and negative sense. For instance, a class of drugs called beta-blockers, commonly prescribed for high blood pressure, often adversely affect the brain's chemistry, causing depression. It simply isn't possible to isolate the brain biochemically from the circulatory system. Medications may have a single intended action, but it is impossible for them to not affect other parts of the body. This often creates unwanted, and sometimes dangerous, side effects (see Talking Back to Prozac by Peter Breggin (ST. Martin's). I have seen very severe toxic reactions to SSRIs-resulting in permanent damage-in susceptible individuals.

Add your comment   CONTINUED      Previous   1  2  3  4  5  6  Next   
About The Author
Dr. Cass is a board-certified psychiatrist, nationally recognized expert and frequent keynote speaker on holistic medicine, with a focus on enhancing mind, mood, energy, and weight loss. She appears regularly on TV including The Dr. Oz Show, The View, and E! Entertainment, as well as numerous radio shows, and national magazines. ...more
Share   Facebook   Buzz   Delicious   Digg   Twitter  
From Our Sponsor
Featured Events
Wellness Inventory Certification Training
     September 16-December 16, 2014
     Teleclass, CA USA
Additional Calendar Links
Wellness, Self Responsibility, Love, dimension!

Home       Wellness       Health A-Z       Alternative Therapies       Find a Practitioner       Healthy Products       Bookstore       Wellness Inventory
Healthy Kitchen       Healthy Woman       Healthy Man       Healthy Child       Healthy Aging       Wellness Center       Nutrition Center       Fitness Center
Free Newsletter      What Doctor's Don't Tell You      Discount Lab Tests      First Aid      Global Health Calendar      Privacy Policy     Contact Us

Disclaimer: The information provided on HealthWorld Online is for educational purposes only and IS NOT intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek professional medical advice from your physician or other qualified healthcare provider with any questions you may have regarding a medical condition.