CHLORAMPHENICOL. An antibiotic with restricted use in the
US because it can cause fatal blood disorders, is listed in
the report as "reasonably anticipated to be a human
carcinogen". The report says the listing is based on
limited evidence from human studies that showed an
increased cancer risk for the occurrence of leukemia after
chloramphenicol therapy.
2,3-DIBROMO-1-PROPANOL, a chemical used as an intermediate
in the production of flame-retardants, insecticides, and
pharmaceuticals, is listed in the report as "reasonably
anticipated to be a human carcinogen" based on strong
evidence of cancer formation from skin painting study in
experimental animals.
DYES METABOLIZED TO 3,3'-DIMETHOXYBENZIDINE are dyes that
have been used to color leather, paper, plastic, rubber and
textiles and are listed in the report because they are
metabolized to 3,3'-dimethoxybenzidine, which is
"reasonably anticipated to be a human carcinogen".
DYES METABOLIZED TO 3,3'-DEMETHYLBENZIDINE are dyes that
have been used in printing textiles, in color photography
and as biological stains and are listed in the report
because these dyes are metabolized to 3,3'-
dimethylbenzidine, which is "reasonably anticipated to be a
human carcinogen".
METHYLEUGENOL, occurs naturally in oils, herbs and spices
and is used in smaller amounts in its natural or synthetic
form in flavors, insect attractants, anesthetics and
sunscreens. It is listed in the report based on sufficient
evidence of cancer formation from oral studies of this
chemical in experimental animals.
METALLIC NICKEL, this metal is used mainly in alloys with
most exposures by inhalation or skin contact in the
workplace. (It should be noted that metallic nickel is not
contained in the nickel coin.) It is listed in the report
based on sufficient evidence of cancer formation from
studies of this chemical in experimental animals.
STYRENE7,8-OXIDE, is used in producing reinforced plastics
and as a chemical intermediate for cosmetics, surface
coatings, agricultural and biological chemicals. It is
listed in the report based on sufficient evidence of cancer
formation from studies of this chemical in experimental
animals.
VINYL BROMIDE, which has been used in polymers in making
fabrics for clothes and home furnishings, as well as in
leather and metal products, drugs and fumigants. It is
listed in the report based on sufficient evidence of cancer
formation from studies of this chemical in experimental
animals.
VINYL FLUORIDE, which is used in making polyvinyl fluoride
and related weather-resistant fluoropolymers. Support for
the listing came from inhalation studies in experimental
animals. It is listed in the report based on sufficient
evidence of cancer formation from studies of this chemical
in experimental animals.
The report is immediately accessible at
http://ntp-server.niehs.nih.gov
For available hard copies, email ehponline@niehs.nih.gov,
visit http://www.ehponline.org or write Environmental
Health Perspectives, Attn: Order Processing, 1001 Winstead
Drive, Suite 355, Cary, NC 27513. Requests for hard copies
may also be faxed to (919) 678-8696.
Fact sheets -- "What is the "Report On Carcinogens"?" and "Q
and A on the RoC" as well as background documents for the
new listings -- can be accessed at
http://ntp-server.niehs.nih.gov/