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New Federal "Report on Carcinogens" Lists Steroidal Estrogens Used in Estrogen Replacement Therapy to List of Known Human Carcinogens

© National Institutes of Health

CHLORAMPHENICOL. An antibiotic with restricted use in the US because it can cause fatal blood disorders, is listed in the report as "reasonably anticipated to be a human carcinogen". The report says the listing is based on limited evidence from human studies that showed an increased cancer risk for the occurrence of leukemia after chloramphenicol therapy.

2,3-DIBROMO-1-PROPANOL, a chemical used as an intermediate in the production of flame-retardants, insecticides, and pharmaceuticals, is listed in the report as "reasonably anticipated to be a human carcinogen" based on strong evidence of cancer formation from skin painting study in experimental animals.

DYES METABOLIZED TO 3,3'-DIMETHOXYBENZIDINE are dyes that have been used to color leather, paper, plastic, rubber and textiles and are listed in the report because they are metabolized to 3,3'-dimethoxybenzidine, which is "reasonably anticipated to be a human carcinogen".

DYES METABOLIZED TO 3,3'-DEMETHYLBENZIDINE are dyes that have been used in printing textiles, in color photography and as biological stains and are listed in the report because these dyes are metabolized to 3,3'- dimethylbenzidine, which is "reasonably anticipated to be a human carcinogen".

METHYLEUGENOL, occurs naturally in oils, herbs and spices and is used in smaller amounts in its natural or synthetic form in flavors, insect attractants, anesthetics and sunscreens. It is listed in the report based on sufficient evidence of cancer formation from oral studies of this chemical in experimental animals.

METALLIC NICKEL, this metal is used mainly in alloys with most exposures by inhalation or skin contact in the workplace. (It should be noted that metallic nickel is not contained in the nickel coin.) It is listed in the report based on sufficient evidence of cancer formation from studies of this chemical in experimental animals.

STYRENE7,8-OXIDE, is used in producing reinforced plastics and as a chemical intermediate for cosmetics, surface coatings, agricultural and biological chemicals. It is listed in the report based on sufficient evidence of cancer formation from studies of this chemical in experimental animals.

VINYL BROMIDE, which has been used in polymers in making fabrics for clothes and home furnishings, as well as in leather and metal products, drugs and fumigants. It is listed in the report based on sufficient evidence of cancer formation from studies of this chemical in experimental animals.

VINYL FLUORIDE, which is used in making polyvinyl fluoride and related weather-resistant fluoropolymers. Support for the listing came from inhalation studies in experimental animals. It is listed in the report based on sufficient evidence of cancer formation from studies of this chemical in experimental animals.

The report is immediately accessible at http://ntp-server.niehs.nih.gov

For available hard copies, email ehponline@niehs.nih.gov, visit http://www.ehponline.org or write Environmental Health Perspectives, Attn: Order Processing, 1001 Winstead Drive, Suite 355, Cary, NC 27513. Requests for hard copies may also be faxed to (919) 678-8696.

Fact sheets -- "What is the "Report On Carcinogens"?" and "Q and A on the RoC" as well as background documents for the new listings -- can be accessed at http://ntp-server.niehs.nih.gov/

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