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N-Acetylcysteine (NAC): An Old Nutrient Attracts New Research

© Richard A. Passwater PhD

71. Metabolic, desmutagenic and anticarcinogenic effects ofN-acetylcysteine.De Flora, Silvio, Rossi, G. A. and De Flora, A.Respiration 30(suppl. 1):43-9 (1986)

72. In vitro effects of N-acetylcysteine on the mutagenicity ofdirect-acting compounds and procarcinogens.De Flora, Silvio, et al,Carcinogenesis 5(4):505-10 (1984)

73. In vivo effects of N-acetylcysteine on glutathionemetabolism and on the biotransformation of carcinogenicand/or mutagenic compounds.De Flora, Silvio, et alCarcinogenesis 6(12):1735-45 (1985)

74. Detoxification of genotoxic compounds as a thresholdmechanism limiting their carcinogenicity.De Flora, S.Toxicol. Pathol. 12(4):337-43 (1984)

75. Effects of N-acetyl-L-cysteine and ascorbic acid onmutagen-induced chromosomal sensitivity in patients withhead and neck cancers.Trazana, Zoltan, et al,Amer. J. Surg. 162:294-8 (1991)

76. Effect of exogenous glutathione on tumor progression in themurine skin multistage carcinogenesis model.Rotstein, J. B. and Slaga, T. J.

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78. N-acetylcysteine as chemoprotectant in cancer chemotherapy.Martinez, Esteban and Domingo, PereLancet 338:249 (July 27, 1991)

79. Long-term oral acetylcysteine in chronic bronchitis: Adouble-blind controlled study.Multicenter Study GroupEur. J. Respir. Dis. 61(Sup.):93 (1980)

80. The reduction in vitro in viscosity of mucoproteinsolutions by a new mucolytic agent, N-acetylcysteine.Sheffner, A. L.Ann. NY Acad. Sci. 106:288 (1963)

81. Toxicological, pharmacokinetics and metabolic studies onacetylcysteine.Bonanomi, L. and Gazzaniga, A.Eur. J. Respir. Dis. 61(Sup):45-51 (1980)

82. AcetylcysteineMerck Index

83. Pharmokinetics of oral acetylcysteine.Rodenstein, D., DeCoster, A. and Gazzaniga, A.Clin. Pharmacokin. 3:247-54 (1978)

84. Clinical pharmacokinetics of N-acetylcysteine.Borgstrom, L., Kagedal, B. and Paulsen, O.Eur. J. Clin. Pharmacol. 31:217-22 (1986)

85. Pharmokinetics and bioavailability of reduced and oxidizedN-acetylcysteine.Olsson, B., et al,Eur. J. Clin. Pharmocol. 34:77-82 (1988)

86. Acetylcysteine: A drug that is much more than a mucokinetic.Ziment, I.Biomed. Pharmacother. 42:513-20 (1988)

87. Pharmacokinetics and bioavailability of oral acetylcysteinein healthy volunteers.De Caro, L., et al,Arzneim.-Forsch/Drug Res., 39:382 (1989)

88. Clinical pharmacokinetics of N-acetylcysteine.Holdiness, M. R.Clin. Pharmacokinet. 20:123-34 (1991)

All rights, including electronic and print media, to this article are copyrighted by Richard A. Passwater, Ph.D. and Whole Foods magazine (WFC Inc.).

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About The Author
Richard A. Passwater, Ph.D. has been a research biochemist since 1959. His first areas of research was in the development of pharmaceuticals and analytical chemistry. His laboratory research led to his discovery of biological antioxidant...more
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