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 Digestive System: Leaky Gut Syndromes: Breaking the Vicious Cycle  

(9) Gamma oryzanol, a complex mixture of ferulic acid esters of phytosterosl and other triterpene alcohols derived from rice bran, has been extensively researched in Japan for its healing effects in the treatment of gastric and duodenal ulceration, thought to be secondary to its potent anti-oxidant activity[152, 153].


Altered intestinal permeability is a key element in the pathogenesis of many different diseases. Hyperpermeability initiates a vicious cycle in which allergic sensitization, endotoxic immune activation, hepatic dysfunction, pancreatic insufficiency and malnutrition occur; each of these increases the leakiness of the small bowel. Effective treatment of the Leaky Gut Syndromes requires several components: avoidance of enterotoxic drugs and allergic foods, elimination of infection or bacterial overgrowth with antimicrobials and probiotics, and dietary supplementation with trophic nutrients. Direct measurement of intestinal permeability allows the clinician to plan appropriate strategies and to gauge the effectiveness of treatment, using objective parameters.

Table 1

Diseases Associated with Increased Intestinal Permeability

Inflammatory bowel disease
Infectious enterocolitis
HIV infection
Cystic fibrosis
Pancreatic insufficiency
AIDS, HIV infection
Hepatic dysfunction
Irritable bowel syndrome with food intolerance
Chronic arthritis/pain treated with NSAIDs
Neoplasia treated with cytotoxic drugs
Celiac disease
Dermatitis herpetiformis
Childhood hyperactivity
Environmental illness
Multiple food and chemical sensitivities

Table 2

Symptoms Associated with Increased Intestinal Permeability

Fatigue and malaise
Fevers of unknown origin
Food intolerances
Abdominal pain
Abdominal distension
Skin rashes
Toxic feelings
Cognitive and memory deficits
Shortness of breath
Poor exercise tolerance


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Leo Galland MD, FACN Leo Galland, M.D. has received international recognition as a leader in the field of Nutritional Medicine for the past 20 years. A board-certified internist, Dr. Galland is a Fellow of the......more
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