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Kava: Is It Safe?

© Hyla Cass MD

The Industry Response
There has been a strong response by the herbal industry to ensure kava's safety. "We are actively proceeding with a number of initiatives on this issue, both within and outside the industry, working jointly with regulators and the scientific community to learn as much as we can about these adverse events and the safety of kava," said John Cardellina, Ph.D., Vice President for Botanical Sciences, Council for Responsible Nutrition.

A coalition of trade associations of the dietary supplement industry are actively engaged in evaluating the information that has been made available by the German regulatory authorities. They have retained a highly regarded professional toxicologist from a leading university to ascertain the nature of the relationship between kava consumption and liver problems. The organizations include the American Herbal Products Association, the Council for Responsible Nutrition, the National Nutritional Foods Association, and the Utah Natural Products Alliance.

Mark Blumenthal of the American Botanical Council emphasized that the information now coming together on kava needs to be scientifically evaluated and addressed. And he noted this is being done by FDA and the trade associations and that "These considerations and cautions represent a prudent approach to the information presently available."

Based on the limited information made available to date, Blumenthal stated that consumers of kava should consider the following if they are using kava products:

Kava should not be used by anyone who has any liver problems, or by anyone who is taking any drug product with known adverse effects on the liver, or anyone who is a regular consumer of alcohol.

Since the reports so far are associated with chronic use, Blumenthal suggests considering that kava not be taken on a daily basis for more that four weeks. (Note: We consider that to be overly conservative, preferring the German Commission E's recommendation of 3 months.)

In addition, Blumenthal noted that consumers should discontinue use if symptoms of jaundice (e.g., dark urine, yellowing of the eyes) occur.

Consumers should consult their primary healthcare provider if they have a history of liver problems or suspect possible liver problems before using kava or continuing its use.

Another possible recommendation is to set maximum doses allowable for kava, given that adverse reactions have been reported in Germany where high doses, above recommended levels, are routinely prescribed. Australia has such a system - with a maximum 125 mg kavalactones per tablet or capsule, 3g of dried rhizome per teabag and 250mg kavalactones maximum daily dose for all forms.

The FDA's Medwatch Program
The FDA has sent a letter to doctors requesting that any adverse events associated with the use of kava products be promptly communicated to FDA's "Medwatch Program." The letter also noted that there were several incidents of "serious injury allegedly associated with the use of kava-containing supplements." There are however, some problems inherent in this reporting system, explained in the box, "Clarifying FDA Allegations."

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About The Author
Dr. Cass is a board-certified psychiatrist, nationally recognized expert and frequent keynote speaker on holistic medicine, with a focus on enhancing mind, mood, energy, and weight loss. She appears regularly on TV including The Dr. Oz Show, The View, and E! Entertainment, as well as numerous radio shows, and national magazines. ...more
 
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