A further wellestablished
effect of EDTA infusion involves the improvement of cell membrane
integrity and consequent protection of mitochondria activity.
If this is happening in the heart muscle itself, such improvement
in cell function (enhanced energy production via enhanced mitochondria
activity) often allows a strong chance of salvaging and regenerating
previously damaged muscle function, with benefits to the heart
and therefore the body as a whole.
Research by Dr C Gallagher
as long ago as 1960 (Gallagher, 1960) showed that the natural
ageing of the mitochondria could be counteracted by use of EDTA.
Not only does EDTA remove
circulating ionic calcium from the blood, but it also acts directly
on improving the function of blood platelets. These (which contain
granules, lysosomes, mitochondria and glucose), along with red
and white blood cells (erythrocytes and leucocytes), make up much
of the 'solid' material suspended in the blood plasma which itself
is made up of a complex of proteinbased substances including
fibrinogen, albumin and globulin, as well as carrying in solution
salts, hormones and a variety of metabolic products and wastes.
Platelets have as a major
function the role of initiating repair of any damaged internal
lining in blood vessels. This they accomplish, under the direction
of prostaglandin hormones called prostacyclin (which discourages
clotting and reduces muscle spasm) and thromboxane (which encourages
muscle spasm and the stickiness of blood), firstly by adhering
to the damaged surface, gradually covering the region of injury,
while at the same time reducing the danger of hemorrhage by encouraging
a degree of coagulation of the blood. As all this happens, the
shape of the platelets alters from a disc shape to a more irregular
form, with radiating filaments known as pseudopodia extending
from them as well as developing inside them. These protective
functions of platelets are therefore lifeenhancing. But,
should the process of organization of clots (coagulation) take
place in a cerebral artery the consequences could well be lifethreatening
and would certainly pose a hazard until it resolved.
Just how EDTA reduces these
dangers is not clear, but it does. The reduction, after use of
EDTA, in the tendency to overcoagulation is thought by some to
relate to the way EDTA removes ionic calcium from the membrane
of the platelet. Or it may be that a more healthy, balanced production
of the prostaglandins which control platelet function and activity
are influenced by the way EDTA inhibits lipid peroxidation, since
prostoglandins are the product of lipids which can be severely
damaged by free radical activity.
Normalizing abnormal cholesterol
and high density lipoprotein (HDL) levels
As we age there is an increasing
tendency for our bloodcholesterol levels to rise. High blood cholesterol
was for many years used alone as a marker of increased risk of
cardiovascular disease. The fashion for blaming all cholesterol
has only partly been reduced in the public mind through education,
but medical practitioners now know that it is only some forms
of cholesterol which pose a real threat the low density
forms (LDL). Indeed the ratio between total cholesterol and HDL
(high density lipoprotein beneficial form) is now used as a clear
indication of relative safety or danger, in terms of being a predictor
of cardiovascular disease.
In a series of simple but
effective experiments, McDonagh, Rudolph, and Cheraskin (1982b)
have shown that EDTA infusion has a markedly beneficial effect
on this potentially serious problem.
The effects on over 200 patients
with varying levels of HDL cholesterol measurements were quite
dramatic. Those who initially showed low levels of HDL rose to
normal levels, those with normal levels remained unaltered, and
those with high levels of LDL (dangerous) dropped to normal ranges after EDTAchelation therapy (supported with vitamin and mineral supplementation).
Thus we see a homoeostatic
(balancing, normalizing) effect after the use of EDTA, since it
supported a return towards normal HDLcholesterol levels,
whether the initial abnormality was high or low.
How long before such change
starts to be significant?
This same team of researchers,
working in a private practice setting, found that: ' . . there
appears to be a significant reduction in serum cholesterol within
the first month or so (range of 1236 days) of treatment
with EDTA . . . in private practice environment, irrespective
of the age or sex of the patient' Excitingly, it was found that:
'. . . those with the highest initial cholesterol scores decreased
about twice as much as those with the lower first score (approximately
17 per cent as against 9 per cent)'
With regard to the ratios
between total cholesterol and HDL, these homoeostatic effects
were measured as follows:
The 'normal, balance between
total cholesterol and HDL is considered to be a ratio of 4.5:1. The McDonagh, Rudolph and Cheraskin team found that those with 'relatively low ratios (under 4.0) tended to rise,
while those with relatively high ratios (over 5.0) tended to
decline, and those in the range 4.04.9 tended to remain
This important research is
deserving of far wider awareness and application since cardiovascular
disease is the number one killer and these risk factors are demonstrably
easy and safe to control or normalize (by EDTA, diet and lifestyle
Removal of calcium
In Chapter 4 we looked at
some of the ways in which cardiovascular disease developed. Once
a localized area of plaque has accumulated in an artery, following
some degree of local irritation and subsequent repair (which the
plaque represents to a large extent), there exists a strong case
for trying to remove any calcium in the plaque in order to prevent
its inevitable build up towards this becoming a complete obstruction. It is the loosely bound calcium in the plaque, held by an electrostatic charge, which prevents the
body from dissolving it. When EDTA is infused it mops up the
ionic (free) calcium in the blood serum, triggering release of parathormone.
This produces a demand for calcium in the blood and this is first mobilized from the calcium deposited in metastatic sites (plaque, soft tissue deposits, etc.), thus allowing the
process of resorption of the plaque material and restoration of
normal arterial status.
However, this does not happen
quickly. It is only by repetitive, very slow infusions of EDTA
that the process takes place safely
Does this not damage bone
and tooth structure?
On the contrary, the status
of bone is enhanced after a series of EDTA chelation infusions.
This is directly related to the influence of parathyroid hormone.
After EDTA infusion there is a rapid removal of ionic calcium
from the bloodstream (the EDTA/calcium complex is excreted via
the kidneys). The resulting drop in circulating calcium stimulates
parathyroid hormone production which results in the removal of
ionic calcium from metastatic deposits (such as occur in plaque).
At the same time a phenomenon occurs in response to parathormone,
described by Doctors Rasmussen and Bordier (1974), in which preosteoblasts
are converted into osteoblasts.
Since osteoblasts are the
cells which form bone, building the osseous matrix of the skeleton,
new bone formation is thus encouraged. This is often confirmed
by Xray examination of bone before and after a series of
According to Cranton and Brecher
Pulsed intermittent parathormone
stimulation, produced by each chelation (treatment) is known to
cause a lasting effect on osteoblasts of approximately three months'
duration. This is a proven effect of EDTA, and one that makes
perfect sense, for it provides a hypothetical explanation for
the three month waiting period for complete benefit following
a series of intravenous EDTA therapy infusions.
Walker and Gordon (1982) suggest
Soft tissue pathological calcium
in plaques or arterial cells continues to diminish in order to
meet the need caused by the increased bone uptake of calcium.
The therapeutic cycle continues long after a series of chelation
treatment has been completed and patients continue to improve
all this time.
They describe the work of
Dr. Carlos Lamar who explained his findings on this topic at the
fourteenth annual meeting of the American College of Angiology
in 1968. Dr Lamar had demonstrated that as calcification of the
blood vessels decreased so did simultaneous recalcification take
place of previously osteoporotic vertebral and femoral bones.
Similarly, metastatic calcium deposits in arthritic joints was
often seen by Dr Lamar to decrease. In such cases deformity often
remained but symptoms of pain and immobility were reduced or absent
after chelation therapy. Walker and Gordon remind us, however,
that chelation itself is not the whole answer: 'Hardened arteries
get softer and softened bones get harder following proper EDTA
chelation therapy where appropriate mineral
supplementation with zinc, magnesium and other minerals is being
given, dietary calcium/phosphorus ratio is balanced and active
exercise undertaken.'[original italics]
The cancer connection
By now the concept of free
radical damage resulting in tissue damage and consequent deterioration
of circulatory function should be quite familiar. It is perhaps
less apparent that free radical damage is frequently the trigger
which leads to malignant changes in previously normal cells. Just
as the first benefits to circulation of EDTA chelation therapy
were discovered during treatment of heavy metal poisoning, so
was the way in which this same treatment could help prevent, and
indeed treat, cancer discovered.
Writing in a Swiss medical
journal in 1976, Dr W Blumen described the strange but potentially
very important discovery. In the late 1950s a group of residents
of Zurich who lived adjacent to a major traffic route were treated
for contamination by lead with EDTA chelation under the auspices
of the Zurich Board of Health. These people had all inhaled large
amounts of leadladen fumes and were suffering from a range
of symptoms identified as being related to lead poisoning, including
stomach ache, fatigue, headache, digestive symptoms, etc. lead
deposits were found to be present in their gum tissues and specific
changes were found in their urine, linking their condition with
high lead levels.
Some years later, in the early
1970s, people living in the same area were being investigated
for the incidence of cancer, in an attempt to link the pollution
with a higher cancer rate than average. This link was easily established
as fully 11 per cent of the residents of the road had died of
cancer over the period 1959 to 1972, a rate some 900 per cent
above that expected when compared with people living in the same
community but not directly affected by lead pollution. The forms
of cancer most commonly related involved the lungs, colon, stomach,
breast and ovary.