Join Now!      Login

Whole Person Wellness Program Wellness Model
Skip Navigation Links
Health Centers
Key Services
Which of the following is an antioxidant?
Vitamin E
Vitamin B

 Natural Hormones: DHEA: Happy 120th Birthday?? 

Do DHEA supplements have a role in hormonal replacement therapy and influence longevity?
I asked the opinions of the world's top researchers:

Michael Bennett, M.D., from the Department of Pathology at the University of Texas, Southwestern Medical Center in Dallas, has been researching DHEA for 9 years, especially its effects on the immune system of rodents.

DHEA does not have the bad effects that androgenic steroids, such as those used by some body builders, have. It is a precursor to estrogen which can possibly lead to breast enlargement in men if used in high doses. In women, high doses could pose the risk of an overabundance in androgens leading to such side effects as hirsutism (excess body hair). Many strains of mice have lived longer when supplemented with this steroid.

I'm 60 years of age. If my blood test showed that my level was low, I would consider taking low doses such as 25 mg to bring my levels higher. However, I would prefer being part of an experiment to test the effects of low-dose DHEA.

Etienne-Emile Baulieu, M.D., Ph.D., Director of the Institut National de la Sante et de la Recherche Medicale (similar to the US NIH), Department of hormone research, Paris, France.
This is my favorite theory. We are studying the possible beneficial effects of re-establishing a "young" level of DHEAS in people over 60 years of age. The comparison to estrogen replacement therapy after menopause is a good one.

However, we need long-term studies to make sure that there are no negative effects on hormone responsive tumors such as prostate and breast. We are currently doing studies on DHEA's role in cerebral function, cardiovascular system, bones, muscles, skin, metabolic (lipids, glucose) and hormonal (pituitary, insulin) parameters. We expect important influences by DHEA on most of these functions.

I would consider taking 25 mg or 50 mg daily if my blood levels were found to be low.

Peter J. Hornsby, Ph.D., from the Huffington Center on Aging, Baylor College of Medicine in Houston, Texas, is an expert on the biosynthetic aspects of DHEA.
We have to do some long-term human experiments. The longest published one is 6 months. That's not long enough for us to know what would happen if we took it for 10 or 20 years. Our knowledge about DHEA is basically what it was a couple of decades ago with estrogen. Even after twenty or so years of research on estrogen, we still don't know its full effects.

Moreover, we really can't extrapolate from rodents to humans because they have very little circulating DHEA(S) levels. Although they do make it, they do so locally in the brain and in gonadal tissues. When DHEA is given to rodents, any dose is basically a pharmacological dose, not a physiological dose.

Maria Majewska, Ph.D., Medications Development Division, National Institute on Drug Abuse, Rockville, Maryland.

While we are waiting for more data, (Dr. Baulieu's group is doing clinical studies at this time in France), the existing evidence already suggests that DHEA(S) replacement may be a safe and effective means of improving health and the quality of life during aging. However, we have yet to learn the right dosages.

John Nestler, M.D., Division of Endocrinology and Metabolism, Medical College of Virginia/Virginia Commonwealth University, Richmond. (As reported in the Annals NY Acad Sci 774: ix-xi, 1995.)
The clinical issues that will have to be addressed include optimal DHEA dosage, form and amount, route of administration, and delineation of side effect profile. It is important that such studies be conducted before DHEA is casually administered to men and women, as some physicians in private practice are currently doing, because DHEA administration may be associated with some untoward effects. For example, DHEA can be converted to potent androgens, such as testosterone, which would masculinize women. Similarly, whether DHEA administration is associated with any change in prostatic volume or risk for prostatic cancer in men is currently unknown.

(Excerpted from DHEA: A Practical Guide ISBN: 0895297744)
CONTINUED      Previous   1  2  3  4  5  Next   
 Comments Add your comment 

 About The Author
Ray Sahelian MDRay Sahelian, M.D., is a popular and respected physician who has been seen on numerous television programs including NBC Today, Dateline NBC, and CNN, and quoted by countless major magazines such as Newsweek He......more
 From Our Friends
Popular & Related Products
Popular & Featured Events
Wellness Inventory Certification Training
     April 3-July 3, 2018
     Los Angeles, CA USA
2018 National Wellness Conference
     June 18-20, 2018
     St. Paul, MN USA
Additional Calendar Links
Dimensions of Wellness
Wellness, Breathing, dimension!

Home       Wellness       Health A-Z       Alternative Therapies       Wellness Inventory       Wellness Center
Healthy Kitchen       Healthy Woman       Healthy Man       Healthy Child       Healthy Aging       Nutrition Center       Fitness Center
Discount Lab Tests      First Aid      Global Health Calendar      Privacy Policy     Contact Us
Disclaimer: The information provided on HealthWorld Online is for educational purposes only and IS NOT intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek professional medical advice from your physician or other qualified healthcare provider with any questions you may have regarding a medical condition.
Are you ready to embark on a personal wellness journey with our whole person approach?
Learn More/Subscribe
Are you looking to create or enhance a culture of wellness in your organization?
Learn More
Do you want to become a wellness coach?
Learn More
Free Webinar